PDTenhace

Cyprus Research and Innovation Foundation – EXCELLENCE, “Enhancing Photodynamic Therapy Efficacy in Cancer Through Tumor Microenvironment Normalization” (EXCELLENCE/0524/0227, “PDTenhance”)

Project Highlight

Key Insights from Our Research Journey

The project proposes to test the hypothesis that the combination of mechanotheraputic drugs that remodel and normalize the tumor microenviroment (TME) with photodynamic therapy (PDT) and the use of multibeam light exposure can increase PDT efficiency

Project Objectives

This project aims to develop new strategies to enhance the effectiveness of PDT by (i) utilizing fiber-based optics for real-time oxygen measurement and improved light delivery, (ii) identifying mechanical-based biomarkers for assessing PDT outcomes, and (iii) creating a novel therapeutic approach combining TME normalization (with anti-fibrotic drugs  that remodel and normalize TME) with PDT to increase its efficiency by overcoming TME barriers. The specific research objectives (RO) are:

►RO.1: Develop fiber-optic tools for real-time assessment of tumor oxygenation and improved light delivery

►RO.2: Identify mechanical-based biomarkers for assessing PDT outcomes

►RO.3: Determine the therapeutic outcomes and mechanisms of the combination of TME normalization treatment with PDT

Project hypothesis. The project proposes to A) treat highly desmoplastic tumors with B) mechanotherapeutic drugs and subsequently C) with PDT with multibeam light to increase anti-cancer treatment efficacy.

Meet the project consortium

Discover our partnerships and how their expertise strengthens our projects.

European University Cyprus

Host organization (HO)

University of Cyprus

Partner organization 1 (PA1)

Lumoscribe LTD

Partner Organization 2 (PA2)

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